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Antacids and Acid Reducers – OTC Relief for Heartburn and Acid Reflux

If you are having any symptoms or have any questions, please call 811 to speak with a registered nurse 24 hours a day.

What types of OTC products treat heartburn?

Over-the-counter (OTC) medicines are medicines you can buy without a healthcare provider’s prescription. There are 3 types of OTC medicines that treat heartburn:

Antacids reduce the effect of (neutralize) the acid in your stomach. They can provide fast, short-term relief. Many OTC medicines combine different antacids.

H2 blockers reduce the amount of acid your stomach makes. While they don’t relieve symptoms right away, H2 blockers relieve symptoms for a longer period of time than antacids. They usually start to work within an hour. Examples of H2 blockers available over the counter are ranitidine (brand name: Zantac) or famotidine (brand name: Pepcid).

Proton pump inhibitors greatly reduce your body’s production of acid. They work well for heartburn that isn’t resolved by antacids or H2 blockers. It may take a little longer for a proton pump inhibitor to help your symptoms than an H2 blocker, but relief will last longer. These medicines are most helpful for people who have heartburn often — more than 2 days a week. Omeprazole (brand name: Prilosec) and lansoprazole (brand name: Prevacid) are examples of OTC proton pump inhibitors.

To find out which medicine is right for you, contact your healthcare provider.

What are some common side effects of OTC antacids and acid reducers?

Antacids and acid reducers usually cause only minor side effects that go away on their own. These may include headaches, nausea, constipation, or diarrhea.

Who shouldn’t take OTC antacids and acid reducers?

If you have kidney disease, you shouldn’t use an antacid containing calcium carbonate or aluminum hydroxide and magnesium carbonate unless your healthcare provider recommends it.

Contact your healthcare provider before taking a proton pump inhibitor if:

  • You are a postmenopausal woman. Proton pump inhibitors reduce calcium absorption from foods and supplements and may increase your risk for osteoporosis.
  • You have been treated for a Clostridium difficile infection in the past. Proton pump inhibitors may increase the risk that your infection will return.
  • You are elderly or have immune system problems. Proton pump inhibitors may increase your risk for pneumonia.

Can OTC antacids or acid reducers cause problems with any other medicines I take?

Don’t use more than 1 antacid or acid reducer at a time, unless your healthcare provider recommends it.

How can I safely store OTC antacids and acid reducers?

Store all medicines up and away, out of reach and sight of young children. Keeping medicines in a cool, dry place will help prevent them from becoming less effective before their expiration dates. Do not store medicines in bathrooms or bathroom cabinets, which are often hot and humid.

When should I contact my healthcare provider?

If you have chest pain that is severe or occurs with shortness of breath, dizziness, or pain in your arms, you may be having a heart attack. Call 911 or go to the emergency room immediately.

Contact your healthcare provider if you have any of the following symptoms:

  • Bloody or black stools
  • Bloody vomit
  • Heartburn that has not improved after 2 weeks of treatment with OTC medicines
  • Trouble swallowing or pain when you swallow
  • Unintended weight loss

These may be signs of a more serious problem.

Funding and support for this material have been provided by the Consumer Healthcare Products Association.

Written by familydoctor.org editorial staff.

Revised/Updated: 10-01-2013

Created: 09-01-2005

This handout provides a general overview on this topic and may not apply to everyone. To find out if this handout applies to you and to get more information on this subject, contact your family healthcare provider.

Copyright (c) by the American Academy of Family Physicians

Permission is granted to print and photocopy this material for non-profit educational uses.

Written permission is required for all other uses, including electronic uses.

Nova Scotia Telecare, Reviewed by Clinical Services Working Group, February 2019

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